IEA/AIE 2022 is sponsored by the International Society of Applied Intelligence in cooperation with sixteen other international organizations. It continues the tradition of emphasizing applications of applied intelligent systems to solve real-life problems in all areas including engineering, science, industry, automation & robotics, business & finance, medicine and biomedicine, bioinformatics, cyberspace, and human-machine interactions. IEA/AIE-2022 will include oral presentations, invited speakers, and special sessions. Paper submission is required by December 15, 2021. Submission instructions and additional details may be obtained from the website: https://ieaaie2022.wordpress.com/